For winning a state? Sure. Though I think VA and NC are going to be in play, it's difficult envisioning Obama taking AL or GA.
But what he will do is increase African-American turnout to previously unseen points - which might not affect a winner-take-all state, but may affect winner-take-all Congressional districts. That means the RNCC has to play defense in a lot of places they didn't have to before - increasing the likelihood of our retaining or increasing our majority in the House.
Also, it may force McCain and other Republicans to spend time in places like VA, NC, SC, etc. rather than in MI, OH, FL, etc. if Obama can run competitively in those southern states.